However, studies on nutraceutics (foods with a medicinal function) lack further explanation, especially regarding the associated protective effects. This functional property concerns the metabolic or physiological role played by the nutrient or non-nutrient in growth, development, maturity and other normal functions of the human organism. Thus, several studies were performed claiming that functional foods are essential for health and have helped reduce the risk of developing various chronic diseases. The purpose of this article is to review the available data regarding the benefits of CLA on the energetic metabolism and body composition, emphasizing action mechanisms.Īlthough many research studies are inconclusive about functional foods, their benefits to health have often been discussed, calling the attention of the scientific community. Moreover, some have shown adverse effects, such as negative effects on glucose metabolism and lipid profile. Although studies made in human have shown some benefits of CLA supplementation as the weight loss, the results are still discordant. CLA supplementation also could increase the lipolysis and reduce the accumulation of fatty acids on the adipose tissue the putative mechanisms involved may be its action in reducing the lipase lipoprotein activity and to increase the carnitine-palmitoil-transferase-1 (CAT-1) activity, its interaction with PPARγ, and to raise the expression of UCP-1. Furthermore, CLA supplementation may modulate the immune function, help re-synthetize of glycogen and potentiate the bone mineralization. The capacity of CLA to reduce the body fat levels as well as its benefic actions on glycemic profile, atherosclerosis and cancer has already been proved in experimental models. Conjugated linoleic acid (CLA) is highly found in fats from ruminants and it appears to favorably modify the body composition and cardiometabolic risk factors.
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